Nearly 90% of cases of type 2-diabetes could be solved by changes in lifestyle simple. In this case, it is important to think about prevention, because diabetes is very difficult to treat and some medicines used to do so can have serious side effects include cardiovascular system.
Type 2 diabetes is on the verge of becoming a national epidemic. In a report published in December 2009, said the Canadian Diabetes Association, the number of Canadians living with diabetes has doubled between 2000 and 2010, jumping from 1.3 to 2.5 million people.
Even worse, it is estimated that between 2010 and 2020, 1.2 million new diabetes cases will be diagnosed, bringing the number of people fighting this disease to nearly 3.7 million. According to the Diabetes Association, this is a “economic tsunami” as costs associated with the disease could reach $17 billion by 2020.
The damage caused by type 2 diabetes is due to the numerous problems stemming from chronic hyperglycemia: a higher risk of cardiovascular disease and some cancers, renal insufficiency, retinopathy, circulation problems in the lower limbs and even serious cognitive issues like Alzheimer’s Disease. Diabetes is not a “benign” disease, as is thought to be the case by many. It is, in fact, a very serious health problem that could lead to serious health consequences to the afflicted.
The danger posed by type 2 diabetes remains high, as the disease continues to be very hard to treat. In fact, despite advances in medicine, the available treatment options are relatively minimal, and the available medications can have serious side effects. The class of medications called thiazolidinedione (TZD) is a good example: even if the compounds are very useful in improving the body’s response to insulin (and thus reducing blood sugar levels), the medication can frequently cause water retention that leads to an increase in blood buy cheap generic valtrex volume. In some cases, this retention is so significant that their blood volume is too much for the heart’s pumping system, potentially leading to major complications.
Recent studies have shown that these side effects are the result of an unexpected action by TZD on the systems involved in the re-absorption of ions and water in the kidneys. In most cells, TZD interacts with a protein called the peroxisome proliferator-activated receptor (PPAR), and this interaction stimulates the synthesis of proteins that improve response to insulin and the entry of glucose into the cells. In the kidneys, however, the interaction of TZD with PPAR causes a completely different response: there is instead a large increase in the retention of sodium and bicarbonate that leads, by the process of osmosis, to a massive entrance of water into the cells. This retention makes it so that patients treated with TZD often see significant weight gain and, in more serious cases, suffer damage to the heart.
Importance of prevention
These observations show that although medicine developed in a way that allows them to interact as specific as possible with a goal, the human genome diversity and complexity of the regulatory system in the body’s physiological make these specifications very difficult to achieve. In general, the vast majority of medications can cause side effects. Thus, although we should be happy for medical progress, which helps us to treat serious diseases, however, we must accept the limitations of these treatment options and to recognize that prevention of these diseases is as important as the treated. This concept is particularly well illustrated by the type 2-diabetes, where a healthy lifestyle based on healthy eating, healthy weights and regular physical activity can give us the opportunity to prevent 90% of cases of this disease and avoid difficulties associated with it.